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Imagine a road trip that allows you to immerse yourself in different cultures, witness changing landscapes and dig into some of the most delectable dishes you’ve ever tasted — all while winding along the water. You can enjoy all of this and more by driving the Great River Road.

 This breathtaking scenic byway follows the Mississippi River through 9 states, weaving through historic landmarks, national parks, charming towns and bustling cities. It’s a picturesque and peaceful alternative to U.S. Highway 61, showcasing some of the best sites across the Midwest and southern states. Along the way, it reveals a patchwork of regional flavors, landscapes and stories that define the heart of America. 

Ready to hit the road? Our Great River Road Trip planner highlights must-see stops and lodging picks along this waterfront byway, as well as travel tips to make your journey smooth and memorable.

Where to Begin Your Great River Road Road Trip

Travelers can start their journey at either end of the Great River Road, with Lake Itasca, Minnesota, in the north and New Orleans in the south. Our route begins at the northern point to showcase the full span of the Mississippi River. Short on time? Jump in at a point that’s most convenient for you. Passing through 9 states, this legendary route connects to many major hubs, making it easy to tailor your itinerary to the time you have.

How Long Should You Plan for the Great River Road Trip?

Stretching more than 2,000 miles, the Great River Road is quite the undertaking. Even without stops, the whole drive would take several days, but the stops make the journey unforgettable. We recommend setting aside 7 to 10 days to truly experience the highlights along the route. You can always skip stops that don’t match your interests for a shorter trip, or browse your road atlas to see if any additional sites catch your eye along the way.

Best Time to Experience the Great River Road

The Great River Road region offers year-round charm. To determine the best time to visit, you just need to decide what sites you want to see and what type of experience you’re craving.

• Spring (March to May): With wild blooms in full swing and mild temperatures ideal for pleasant outdoor adventures, spring is a striking time to explore the Great River Road without the summer crowds.
• Summer (June to August): Expect heat and humidity, but with the close proximity to the river, refreshing cool-off spots are always nearby. You can also catch some fun summer festivals, but make reservations early since it’s peak season.
• Fall (September to November): The fall foliage is stunning along the river, making autumn the ideal time for photographers and hikers to visit. Plus, cooler temperatures make it more comfortable to explore midday. You’ll also benefit from fewer tourists. 
• Winter (December to February): The quaint towns and bustling cities quiet down during winter. This is the time to go for those seeking a peaceful, off-season experience. You might even witness a partially frozen Mississippi River. Just keep in mind that some attractions might be closed.

Every season lends a unique appeal to the Mississippi River, so there’s no wrong time to drive the Great River Road. Whether you plan your trip around your interests or schedule, you won’t be disappointed.

Driving the Great River Road: Must-See Stops and Where to Stay

Whether you’re cruising the entire route or just tackling a segment, the Great River Rd offers a front-row seat to some of the most scenic and culturally rich parts of the country. Our Great River Road trip planner highlights a few top stops in each state along this iconic byway so you don’t miss out on exploring these road trip favorites. Get ready to sample the best that Americana culture has to offer.

1. Minnesota

Minnesota will steal your heart with bustling cities like Minneapolis and St. Paul, noteworthy historic sites and natural wonders. Here are the Minnesota stops you don’t want to miss.

Lake Itasca State Park

At the headwaters of the Mississippi River, Lake Itasca is the ideal place to kick off your trip. Its old-growth pine forest offers a stunning backdrop for enjoying miles of hiking trails. Lake Itasca is one of the best parts of the Great River Road for those after epic natural beauty. Pop by the historic Douglas Lodge, a rustic log cabin built in the early 1900s and the oldest building in the state park system. Visitors can enjoy a meal or book a room in this lakeside relic. 

Minneapolis

Next, you’ll continue on the Great River Road in Minneapolis for a dose of art, history and culture. Enjoy a stroll in Gold Medal Park. With its 300-foot mound containing a spiraling walkway, the park has won awards for its design, and once you see it, you’ll understand why. Stop by the Minneapolis Sculpture Garden to peruse more than 40 renowned works of art. Catch a show at the Guthrie Theater, which is said to be an incubator for the next generation of great theater minds.

St. Paul

Continue on to St. Paul to explore the city’s historic architecture, like the F. Scott Fitzgerald House, where the famous author wrote the manuscript for his renowned novel, “This Side of Paradise.” Visit the Minnesota History Center, where a series of exhibits, including interactive and multimedia offerings, give a peek into the state’s past. Get some fresh air along the riverfront walk, where you’ll find well-maintained green spaces and the Science Museum of Minnesota.

Lake City

Lake City’s unique location near Lake Pepin makes it a highly visited spot along the Great River Road. Lake Pepin marks the widest spot of the Mississippi River, and is the reported birthplace of water skiing (its massive surface certainly lends itself to the sport). Head into town and check out the funky, artsy boutiques on South Washington Street for artisan goods.

Great River Bluffs State Park

Stretch your legs at Great River Bluffs State Park, known for its numerous scenic overlooks with views of the Mississippi River, nearby bluffs and prairie land. If you’re looking for an easy, mostly flat hike, try King’s Bluff. It leads to panoramic views of the Mississippi River valley, forests and goat prairies.

Where to Stay in Minnesota

Want to rest your head in some historic digs? Book a room at the Saint Paul Hotel. Open since 1910, the property has hosted high-profile government officials and celebrities and is known for its Renaissance Revival architecture. After quaint B&B vibes? Stay at the 300 Clifton Mansion in Minneapolis, situated in the heart of downtown.

2. Wisconsin

Next, you’ll experience classic Midwestern charm in Wisconsin. From its rolling green hills to its welcoming lake towns, the Great River Road in WI will show you why it has a reputation for kindness and natural beauty.

Prescott

Prescott sits where the St. Croix River and the Mississippi River merge. This is where you’ll find the Great River Road Visitor and Learning Center, the perfect place to gather insights into this byway. The center contains exhibits on the local nature, an art gallery featuring works from local artists and on-site volunteers ready to educate you on the area’s history and significance.

Maiden Rock

Just an hour south of the Twin Cities is the quaint village of Maiden Rock. Don’t let its small size fool you, though; Maiden Rock contains a stretch of Highway 35 that is a contender for one of the longest Main Streets in America. Hop out of your car and hike to Maiden Rock Bluff, a nature preserve with trails that take you to views of the river valley. Hungry? Hop over to the Six String Saloon, where you can enjoy comfort food, live music and water views.

Trempealeau

Another endearing small village on the banks of the Mississippi River, Trempealeau, is popular because it houses Perrot State Park. Boasting a variety of landscapes, from wooded areas to marshland and bluffs, the park won’t disappoint nature lovers. Once you’ve exhausted your legs, you can rest them in one of the cute cafés or restaurants in the historic downtown district, known for its whimsical buildings and its designation on the National Register of Historic Places.

La Crosse

This beloved college town (city, technically) has just the right blend of action and relaxation. Enjoy an afternoon at Riverside Park, where you can check out a coy pond and sculptures, while watching river cruises float by. Car lovers can’t miss the Dahl Auto Museum, which houses dozens of classic and antique vehicles.

Where to Stay in Wisconsin

Stay steps away from the river at the Radisson Hotel La Crosse, which has affordable rooms and an on-site restaurant serving up local microbrews and flatbreads. Spending the night in Trempealeau? The Trempealeau Hotel is a must-see historic property. Built in 1851, it was one of the only buildings to survive a devastating fire in 1888. Its on-site restaurant features local ingredients, and its saloon has live music nights.

3. Iowa

Iowa is so much more than farm country (though it’s certainly rich with pastoral charm). Its vibrant art communities and lively street fairs provide entertainment, while its natural landscapes offer a soothing effect.

Marquette

This tiny village is where Effigy Mounds National Monument is located, the site of more than 200 Native American burial mounds. The mounds — often shaped to look like local wildlife — give insights into the ceremonial practices of the ancient people of the land. When you’re ready to congregate with the living, head to Tucked Away Grill for American fare and river vistas.

Dubuque

Dubuque is the oldest city in Iowa and is home to several unique attractions. Visit the National Mississippi River Museum & Aquarium for water-centric wonders, like the Down in the Delta exhibit with a stingray touch pool and mangrove habitat. Then, head over to the Fenelon Place Elevator. A quirky stop, the elevator is the world’s shortest and steepest scenic railway, reaching just 296 feet in length. From the top, you’ll enjoy views of Dubuque, Illinois and Wisconsin.

Bellevue

For a blend of nature, history and archaeology, make a stop at Bellevue State Park. Said to have one of Jackson County’s most scenic river overlooks, this park sits on a 250-foot limestone bluff and has several hiking trails. It also houses a butterfly garden — the ideal place for artists to take out a sketchbook. Meanwhile, downtown Bellevue contains several historic buildings, some dating back to the late 1800s.

Keokuk

Explore the rich history in Keokuk, a site of several significant Civil War events. Visit the George M. Verity Riverboat Museum, an out-of-service towboat and one of the country's only three remaining steam-powered towboats. You can take a guided tour of the boat and see what life as a crew member of the Keokuk was like in the 1920s. For a morose but meaningful stop, pay your respects at the Keokuk National Cemetery, the final resting place of over 600 Union soldiers and eight Confederate prisoners.

Where to Stay in Iowa

When you’re ready to rest, book a room at the iconic Hotel Julien Dubuque in the historic Old Main district. For a more rustic experience, consider booking a waterfront tiny home at the Riverview Vacations Resort in Bellevue.

4. Illinois

Illinois is a hub of innovation and artistry, yet it still possesses undeniable Midwestern charm. Below are the top sights that show you all the Prairie State has to offer.

Rock Island

Part of the popular Quad Cities region, Rock Island is home to the John Deere Pavilion, where you can check out historic equipment from the namesake inventor and enjoy interactive displays. Ready for a picnic? Schwiebert Riverfront Park is the perfect spot. Situated on the riverfront and in the heart of downtown, the park provides opportunities for people watching and water views. Don’t skip The District, an arts and entertainment hub known for its galleries, theaters, pubs and comedy clubs.

Galena

Galena fuses historic intrigue with modern allure. This former home of Ulysses S. Grant is known for its streets filled with restored 19th-century buildings, housing welcoming boutiques and antique shops. Its main street has over 100 art galleries bursting with creative energy. For a friendly atmosphere and satisfying meal, head to Chubz Pub Grub. 

Chicago

It’s time to visit Chi-town for some architectural wonders and big-city energy. Stop by the Art Institute, one of the country’s largest and oldest art museums. Established in 1879, the museum houses works by great artists, including Van Gogh and Edward Hopper. Enjoy a river cruise for a unique view of the city’s skyline. Stop by Wrigleyville to witness serious Cubs fans living it up at the various sports bars.

Shawnee National Forest

The Great River Road runs through parts of the Shawnee National Forest, so nature enthusiasts can stretch their legs at this famous site. Visit the Garden of the Gods, which has been described as a “Paradise on Earth” because of its pristine panoramic views of the Shawnee Hills. Explore the Little Grand Canyon, abundant with natural attractions including bluffs and waterfalls.

Where to Stay in Illinois

Plan on exploring the Quad Cities? There’s an entire booking platform dedicated to properties across the region, ranging from boutique stays to casinos and familiar franchises. For a social vibe and affordable rooms in Chicago, consider the HI Chicago hostel. It’s steps away from major attractions and arranges regular tours and activities. 

5. Missouri

Missouri is where Midwest warmth and Southern charm meet. You’ll begin to hear soul music piping through the air and catch glimpses of the epic Ozarks. Here are the most memorable Missouri stops on the Great River Road.

Hannibal

Visit a city that produced one of America’s greatest writers: Mark Twain. Be sure to visit The Mark Twain Boyhood Home & Museum to tour his childhood home. Not far from the house, you’ll find the Mark Twain Cave, a natural feature that inspired many of the author’s greatest stories. Looking for luxury? Head over to Rockcliffe Mansion. Built in 1902, this elaborately furnished mansion was long the site of high-society events and now serves as a bed and breakfast.

St. Louis

Take in the energy of St. Louis, a hub of innovation and creativity. See the Gateway Arch, the world’s tallest arch and the country’s tallest monument. Check out the St. Louis Cardinals Museum at Ballpark Village for exhibits containing artifacts and memorabilia that teach you about the team’s legacy. Explore the Old Courthouse, where some of the most important American court cases took place (including Virginia Minor’s fight for a woman’s right to vote).

Ste. Genevieve

Travel to France by way of Missouri in Ste. Genevieve, a city known for its captivating French Creole architecture. The Felix Valle House State Historic Site, the Bauvais-Amoureux House and the Green Tree Tavern are some of the most notable structures. Wine lovers can spend a day on the Route du Vin Wine Trail, a self-guided tour of the picturesque wineries in the area, many of which have on-site farm-to-table restaurants.

Where to Stay in Missouri

Ready for some rest? Book a room at the Drury Plaza Hotel St. Louis at the Arch, which boasts an 8-floor terrace offering views of the Gateway Arch and proximity to other major attractions. Rest your head at The Inn St. Gemme, located in Ste. Genevieve’s historic district. Built in 1848, this charming historic bed and breakfast is surrounded by specialty shops, galleries and restaurants.

6. Kentucky

Entering the true American South now, you’ll experience the rich heritage, small towns and lush landscapes of Kentucky. Get ready to learn a little history in a laid-back environment.

Cairo

Ready for a break from driving? Stop at Cairo, where the Ohio River meets the Mississippi River. As one of the largest water confluences in the world, you’ll want to have your camera at the ready. Here, you can visit Fort Defiance, a former military fort that played a significant role in the Civil War. In 1803, Lewis and Clark trained their crew in their navigational equipment at this very site.

Paducah

Paducah is a truly rare gem because it received the UNESCO Creative City designation for its vibrant arts scene. Nothing represents that culture quite as well as the National Quilt Museum, where you can witness fiber art and quilting exhibits from around the world. While you’re in town, snap a photo in front of the Wall to Wall, a colorful mural depicting the town’s history. Grab a bite at Flamingo Row, a Caribbean restaurant with bright, tropical decor that’s just right for this visually intriguing city.

Wickliffe

Wickliffe itself is a small city, but it makes our list because it’s the home of the Wickliffe Mounds State Historic Site, a prehistoric archaeological site. Here, visitors can see artifacts such as tools and pottery that were excavated on-site, which provide a glimpse into the lives of Native American cultures dating back to A.D. 1100-1350. 

Where to Stay in Kentucky

It’s time for some shuteye, and if you want to stay in Paducah, we recommend The 1857, a unique, boutique hotel that combines modern amenities with industrial design. There are also several campgrounds along this stretch of the Great River Road, including Fern Lake Campground in Paducah, complete with fire pits, bath houses and other convenient amenities.

7. Tennessee

Music lovers can fill their hearts and foodies can fill their stomachs across the soulful state of Tennessee. Meanwhile, history and nature lovers will find no shortage of sights that spark their curiosity and sense of adventure.

Tiptonville

For a mesmerizing, one-of-a-kind sight, head to the Reelfoot Lake inside Tiptonville. This sureal landscape will bend your brain; severe earthquakes in the early 1800s caused parts of the Mississippi River to flood a cypress forest. Today, the trees appear to emerge from the water, reminding you of the long-lost grounds submerged deep below the surface.

Nashville

Experience the unique blend of cowboy culture and big city vibes in Nashville. Another major music destination, Nashville, is home to the Country Music Hall of Fame. Check out the “Sing Me Back Home: A Journey Through Country Music” exhibit, which shows the evolution of the music genre. Head to the Broadway district to dance and drink at its famous honky-tonk bars and pick up a pair of handmade cowboy boots at one of the many shops slinging the footwear.

Memphis

Enjoy the rhythm of Memphis, starting on Beale Street, the “Home of the Blues.” This electric entertainment district has countless clubs and lounges to weave in and out of to enjoy live tunes. Ready to step back in time? Pay a visit to the National Civil Rights Museum, home to exhibits that dive into the history of the museum’s namesake movement. One such exhibit is Room 306 of the Lorraine Motel, preserved exactly as Dr. Martin Luther King, Jr. left it moments before he was tragically shot. For a mix of music and history, head to Graceland, the former home and final resting place of Elvis Presley, the King of rock ‘n roll.

Where to Stay in Tennessee

Sleep in a slice of history at the Peabody Memphis, a legendary hotel built in 1869 and designated on the National Register of Historic Places. Traveling with a group or on a budget? Stay at the Gallatin Hotel in Nashville. It has double-bunk bed suites for large parties and compact “cozy” rooms for thrifty travelers.

8. Mississippi

Now it’s time to soak in Mississippi’s stately historic homes, enchanting Delta landscapes and rich heritage. History buffs and the culturally curious will find plenty to explore in this storied state.

Great River Road State Park

A Great River Road trip wouldn’t be complete without a stop at the byway’s namesake park. This idyllic destination is popular for fishing and boating, and has several scenic overlooks along with paved walking trails. It’s the perfect place to relax before getting back in the car and traveling to the final state of this itinerary.

Vicksburg

Visit a pristinely preserved battlefield that hosted a key fight in the Civil War at Vicksburg National Military Park. Here, you can explore reconstructed trenches, monuments and a restored battleship, the USS Cairo. For a lighter history lesson, head to the Biedenharn Coca-Cola Museum. Vicksburg was the site of the first cola bottling, making it a fitting place for a museum dedicated to the soda’s history.

Natchez

Stroll the streets of the oldest city on the Mississippi River, Natchez. It’s home to iconic heritage homes, many of which are nestled in the historic downtown area. Check out Longwood, the largest octagonal-shaped house in America. Craving comfort food and tunes? Since Natchez is the “Biscuit Capital of the World,” there’s no better place to fill your stomach than at Biscuits and Blues, an intimate restaurant serving up Southern dishes alongside blues music.

[future opportunity to insert a CTA + link to the Natchez State Parkway blog we’ll write in July!]

Where to Stay in Mississippi

Looking for a hotel that blends classic Southern charm with modern-day amenities? Book a room at the Natchez Grand Hotel, located downtown. For quaint, affordable accommodations right on the water in Vicksburg, check out the Sunset View Resort & Lodge.

9. Louisiana

Your journey now takes you through moss-draped oaks and past Louisiana’s historic estates. From the lively energy of Bourbon Street in New Orleans to the architectural gems of Baton Rouge, Louisiana is a feast for the eyes, ears and palate.

St. Francisville

Begin your Louisiana tour in St. Francisville, a town known for its rich history and well-preserved 19th-century architecture. Visit Rosedown, a landmark estate with a complex past that’s recognized on the National Register of Historic Places. Then, head to the historic downtown area to explore boutiques and antique shops housed in buildings ranging from classic to quirky.

Baton Rouge

Make your way to Baton Rouge to experience a dynamic mix of Cajun and Creole culture and striking government architecture. Visit the Louisiana State Capitol and head to the 27th-floor observation deck for panoramic views of the city. Then, head over to the Old State Capitol, where you can explore the Museum of Political History, marvel at its Gothic and Victorian architecture, and climb the famous cast-iron staircase.

New Orleans

Next, you’ll finish your trip in New Orleans. Enjoy live music and culinary delights like beignets and gumbo in the French Quarter. Stroll the streets with their stunning ironwork balconies and prominent colonial heritage architecture. It wouldn’t be a visit to NOLA without a walk down Bourbon Street (perhaps with a big, colorful drink in hand). Satisfy your ghoulish side with a ghost tour in one of the most haunted cities in the world. 

Where to Stay in Louisiana

When you’re ready to recharge, book a room at the Bourbon Orleans Hotel. Situated in the French Quarter, the hotel’s balconies offer sweeping views of the lively neighborhood. For cozy accommodations in Baton Rouge, consider The Stockade, a small Bed and Breakfast with lavishly decorated rooms and a friendly staff.

Tips for a Smooth Mississippi River Road Trip

Ready to hit the road? Now that you know the best places to stop for adventure, enrichment and entertainment, let’s cover a few tips to keep your trip running smoothly.

• Plan for Traffic: Rural areas offer open roads, but time your visits to major cities like Chicago or St. Louis wisely. Morning and evening rush hours can cause delays, so aim to arrive outside of peak times.  
• Pack Light but Smart: Since you won’t be staying in one place for long, pack light. Essentials include sunscreen, a first-aid kit, a portable charger and layers for changing weather. Don’t forget sturdy hiking boots and pack a swimsuit if you plan to hit the water.
• Expect Limited Cell Service: Some rural areas along the river may have limited or no cell service. Download offline maps and have physical road maps for backup. 
• Read Your Map: The Great River Road’s road markers are notoriously hard to spot — sometimes obscured or set far from the road — making navigation tricky in places. Stay on track by tracing the route on our Central U.S. map and Eastern U.S. map as you move through each region.
• Allow Extra Time: This road trip is about enjoying the journey. Give yourself ample time to stop at scenic overlooks and quirky roadside attractions. 
• Reserve Lodging Early: This is particularly important in small towns with limited lodging options and at campsites during peak season.

With these tips in hand, you’re ready to experience what life along the Mississippi River has to offer.

Plan Your Great River Road Trip with Rand McNally Maps

The Great River Road is more than just a byway — it’s an unforgettable journey. Each state along the route offers rich culture, historical sites and breathtaking natural beauty. 

Make sure you never miss a noteworthy stop — or your exit — with Rand McNally maps and atlases. Featuring detailed graphics, clearly marked routes, points of interest, hiking trails and other helpful insights to help you map your Great River Road trip, our classic paper products let you put your phone down and fully soak up the scenery. So pack your camera and sense of adventure — it’s time to go with the flow of the Mississippi River.